The area of the buttocks where the injections are given is called the gluteus maximus muscle, which is usually the location where the intramuscular injections are performed. The skin where the injections are performed is chosen to be free of inflammation, infection, hardness, and scarring. Usually in the buttocks using the criss-cross method, the buttocks are divided into four equal parts, the outer upper part is chosen, and the middle criss-cross area is avoided for intramuscular injections. This is because there is a possibility that the sciatic nerve may be present in the criss-crossed area, and there is a possibility that the nerve may be damaged when the injection is performed. After the needle is inserted, the needle should be withdrawn to see if it has been injected into a blood vessel, and if it is determined that it has not been injected into a blood vessel, then the drug can be pushed slowly and injected intramuscularly. In the process of intramuscular injection, the patient’s buttock muscles can not be forcefully contracted, because this will affect the injection of drugs.