The normal value of total bilirubin is 3.4-17.1 μmol/L. Total bilirubin of 40 μmol/L is considered to be elevated, which may be caused by physiologic and pathologic factors. physiologic factors do not need special treatment, while pathologic factors are often caused by liver diseases and extrahepatic diseases, which should be treated promptly. 1. Physiological factors: physiological jaundice of newborns appears 2-3 days after birth, which is related to the immaturity of liver function of newborns and other factors. Physiological jaundice does not need special treatment, jaundice can go away by itself, reasonable feeding and appropriate sun exposure can help jaundice go away. Patients with mildly elevated bilirubin caused by work and rest, diet and other factors usually do not need treatment, and regular checkups are sufficient. 2. Pathologic factors: (1) Liver disease: viral hepatitis, alcoholic liver disease, autoimmune liver disease and other liver disease can cause bilirubin elevation, patient often accompanied by aminotransferase different degree of elevation, patient should further improve the viral hepatitis antibody, antinuclear antibody, imaging and other examination, should be given to the polyene phosphatidylcholine, gardenia yellow, adenosine methionine and other medicines to protect the liver, reduce jaundice treatment. (2) Extra-hepatic disease: hemolytic jaundice, bile duct obstruction, cholelithiasis and other extra-hepatic diseases also can cause bilirubin to rise. Treatment mainly focuses on removing the cause of the disease, and patients with hemolytic jaundice can be given glucocorticoids, plasma replacement, bone marrow transplantation and other treatments. Obstructive jaundice can be removed in time through surgery, total bilirubin can also be reduced by itself, and in severe cases, combined with anti-yellowing drug treatment. Of course, the total bilirubin elevated need treatment should be based on the specific circumstances, it is recommended to consult a doctor in a timely manner, under the guidance of the physician to identify the causes, to formulate a plan, so as not to delay the condition.