Helicobacter pylori, the culprit of upper gastrointestinal tract inflammation, ulcers, tumors, and human beings have entangled grudges and feuds, often characterized by this and that, lost and returned, and repeatedly disappeared again and again will recur, and even make many people at their wits’ end. As early as the 1870s years, some German anatomists have found the gastric mucosa spiral-like bacteria exist, they have tried to isolate the culture of this bacteria, but unfortunately unsuccessful, and then slowly faded into oblivion. About 20 years later, an Italian doctor also observed a spiral-shaped bacteria on the surface of the gastric mucosa, but unfortunately, he did not further research. 1899, Walery Jaworski from Poland found the spiral-shaped bacteria from the gastric lavage fluid, which he called Vibrio vulnificus, and speculated that it might be the causative agent of gastritis, and then became the first person to put forward this doctrine. It was not until Dr. STEER published an article in the Journal of Clinical Pathology in 1975, in which the presence of this spiral-shaped bacterium in the gastric mucosa was observed for the first time with an electron microscope and named Helicobacter pylori, that the study of Helicobacter pylori began to catch fire. H. pylori parasites are gram-negative bacteria that are primarily found in the tissues of the gastric mucosa, and studies have found that approximately 67-80% of gastric ulcers and 95% of duodenal ulcers are caused by H. pylori. They can lead to chronic gastroduodenal mucosal edema, inflammation, ulceration and other lesions, the appearance of postprandial epigastric fullness, discomfort or pain, and hunger pains, often accompanied by other uncomfortable symptoms, such as belching, abdominal distension, acid reflux, etc., and in some patients, recurrent severe abdominal pain and a small amount of upper gastrointestinal bleeding can also be observed. It is usually believed that Helicobacter pylori infection through the mouth, after reaching the gastric mucosa to settle the infection, after weeks or months of process, and then triggered chronic superficial gastritis, and then after a few years or even decades after the development of duodenal ulcers, gastric ulcers, lymphoproliferative gastric lymphoma, chronic atrophic gastritis, etc, and can lead to the occurrence of gastric cancer. Studies have found that H. pylori infection increases the risk of stomach cancer by 2.7-12 times, and that at least 35-89% of stomach cancers could be avoided without H. pylori infection. The headache is that H. pylori infection is obviously easy to recur, and often recurs again soon after cure, becoming a long-lasting problem that many patients have lost confidence in, and many doctors are baffled as to why it comes back when it has clearly been driven to extinction. Helicobacter pylori can be detected by gold standard urease test, carbon 13, carbon 14 whistle test, rapid urease test, gastroscopy specimen bacteriology test, etc. The safest clinical method is rapid urease test. Carbon 14 test is fast, false positive rate is low, so the use is also very common, but because there is a certain degree of radioactivity, the use of relative limitations, pregnant women, pediatrics, and preparation for the pregnancy of the crowd should be carefully selected. In fact, Helicobacter pylori is not a special drug-resistant bacteria, commonly used drugs for the treatment of Helicobacter pylori such as clarithromycin, levofloxacin, hydroxybenzylpenicillin, gentamicin bismuth carbonate capsules, amoxicillin and so on, are very sensitive, with the treatment of proton pump inhibitor omeprazole, a single cure is not a difficult task. Just Helicobacter pylori many people only know purely drug treatment, but not at all. This is a bacterial infection spread through the digestive tract eating, can be transmitted through the “fecal-oral” pathway and “oral-oral” pathway, so the patient himself must always maintain good personal oral hygiene, and at the same time, need to be with the patient often share meals with all the people! At the same time, it is necessary for all the people who often share meals with the patient to be treated together, otherwise, even if the disease is cured, it will soon be infected again and recur. Patients themselves must do separate use of fixed tableware, after each meal tableware should be boiled sterilization, so that the cure is much easier. Healthy people should also do to minimize meals with patients, the best implementation of meal sharing system, to maintain oral health and hygiene, do not drink raw water, raw vegetables and fruits should be thoroughly cleaned, tableware should also be frequently disinfected, a healthy lifestyle, is the best way to prevent Helicobacter pylori infection.