A white blood cell count of 22.5×10^9/L suggests that there may be acute infection, acute hemorrhage, etc. Intravenous medication may not be necessary, and the specific routes of administration and therapeutic approaches need to be judged comprehensively. 1. For acute infectious diseases such as pneumonia, urinary tract infection, local tissue infection and other acute infectious diseases due to acute infection, if the white blood cell count reaches 22.5×10^9/L, it suggests that the infection is more serious, and it is necessary to use sensitive antibiotics such as penicillin and other anti-infective treatment, which can be taken orally or intravenously, and it is not necessarily necessary to be infused with fluids. However, for the combination of water and electrolyte disorders, it is recommended to use intravenous rehydration. 2. For acute infectious diseases caused by acute hemorrhage, especially acute internal hemorrhage, if the white blood cell count reaches 22.5×10^9/L, there is a manifestation of hemorrhagic shock, which requires intravenous rehydration or transfusion of blood components, and at this time, it is necessary to carry out intravenous fluids or blood transfusion. During the intravenous infusion, attention should be paid to whether there are reactions such as swelling and rash at the injection site, and the infusion should be stopped if the above manifestations exist. The infusion must be performed by a healthcare professional; the above medications should be used under the guidance of a clinician; the presence of an abnormally high white blood cell count may be due to other reasons, and timely consultation with a hospital is recommended.