Thumb joint pain may be caused by tenosynovitis, gout and rheumatoid arthritis, etc. Drugs should be selected according to the specific disease that causes the symptom, and commonly used drugs include non-steroidal anti-inflammatory drugs such as diclofenac, colchicine and uric acid-lowering drugs such as febuxostat. 1. Tenosynovitis: strain, trauma, infection and other factors can lead to inflammation of the tendon sheath, tenosynovitis is divided into tuberculous tenosynovitis, septic tenosynovitis, acute fibrous tenosynovitis, etc. Different types of tenosynovitis can be chosen from non-steroidal anti-inflammatory drugs, such as naproxen, diclofenac, anti-tuberculosis drugs such as ethambutol, isoniazid and other antimicrobials such as gentamicin and penicillin, and other antibacterial drugs for treatment. 2. Gout: If there are urate crystals deposited in the thumb joint and surrounding soft tissues of patients, it may lead to inflammation. The treatment of gout patients is divided into acute attack and remission treatment, and the commonly used medicines in the acute attack period include non-steroidal anti-inflammatory drugs such as etoricoxib, diclofenac, and colchicine, and the remission period should be treated with uric acid-lowering medicines such as febuxostat, allopurinol, and so on, to control the level of uric acid. 3. Rheumatoid arthritis: Rheumatoid arthritis can involve the peripheral joints of the patients and lead to pain and swelling of the thumb joints, etc. The treatment of rheumatoid arthritis is based on the use of anti-rheumatic drugs such as lorazepam, tofacitib and non-steroidal anti-inflammatory drugs such as diclofenac and indomethacin. Drugs should be used under the guidance of a physician, thumb joint pain may also be caused by other reasons, it is recommended that patients to the regular hospital orthopedics, rheumatology and immunology and other related departments to clarify the diagnosis and treatment as prescribed by the doctor.