Itching after cholecystectomy may be caused by allergy, drug rash, environmental factors and other reasons. 1. Allergy: When the human body comes into contact with allergens such as dust and pollen, the immune system will produce antibodies against them, causing the release of various allergic mediators and leading to itching and flushing of the skin. 2. Drug rash: also known as drug dermatitis, is a drug through a variety of ways into the human body caused by the skin, mucous membrane inflammatory lesions. In severe cases, high fever and other systemic symptoms, and can involve other systems of the body, while inducing itchy skin and other symptoms. 3. Environmental factors: it may be the dry weather after the operation, so that the skin lack of moisture caused by. It is also possible that the weather is hot in summer, due to the high humidity in the air, sweat can not be discharged, resulting in skin discomfort and itchy phenomenon. In addition, after cholecystectomy itchy patients go to the hospital in a timely manner, follow the doctor’s instructions for treatment, to avoid delaying the condition.