Perimenopausal-like manifestations will occur after injection for adenomyosis. Drug treatment for adenomyosis usually refers to the use of gonadotropin-releasing hormone agonist treatment, and commonly used drugs include leuprolide and goserelin. These drugs will inhibit the function of the ovaries, leading to a decrease in the level of estrogen in the body, so there will be manifestations similar to perimenopause, such as hot flashes, sweating, palpitations, headache, easy fatigue, sleep disorders, decreased concentration, memory loss, etc. However, after stopping the medication, the symptoms will disappear when the ovarian function is restored. After 3 to 6 months of gonadotropin-releasing hormone agonist treatment for adenomyosis, the uterus will reenlarge and symptoms will reappear, which can be managed long-term with the aid of other treatments, such as intrauterine use of the levonorgestrel intrauterine device. Adenomyosis should be treated as prescribed by your doctor, and you should talk to your doctor if you experience any discomfort after the injections.