Seronegative spondyloarthropathies generally refer to spondyloarthritis, a group of chronic inflammatory rheumatic diseases involving the spine and peripheral joints, including ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease arthritis and other diseases. 1, ankylosing spondylitis: the onset may be related to genetics, infection, immune inflammatory factors, changes in bone metabolism and other factors, such as Chlamydia trachomatis, Shigella, Salmonella and other infections that cause inflammation of the body The symptoms of lower lumbosacral pain and discomfort, morning stiffness, joint pain, joint swelling, etc.; 2, psoriatic arthritis: due to abnormal autoimmune function, genetic factors, viral or bacterial infections and other factors can appear skin rash, silvery white scales on the skin surface, but also nail depression, discoloration, etc. and joint swelling, pain, stiffness, etc.; 3, inflammatory enteropathic arthritis: due to autoimmune 3, inflammatory enteropathic arthritis: due to autoimmune disorders, genetic factors, can appear abdominal pain, bloating, diarrhea and other gastrointestinal symptoms, or joint swelling and pain and nodular erythema, but also eye pain, eye redness, photophobia, tearing, blurred vision and other eye symptoms.