The main function of pentavalent rotavirus vaccine is to prevent rotavirus gastroenteritis and is a form of active immunization. Rotavirus is the main pathogen causing acute gastroenteritis in infants and children under 5 years of age, and rotavirus vaccine is one of the effective ways to prevent this disease. Through bioengineering technology, this vaccine contains 5 attenuated human-bovine rotavirus reassortant strains, which can prevent viral gastroenteritis caused by five serotypes of rotavirus, G1, G2, G3, G4, and G9, to a certain extent. It is restricted to oral administration and is contraindicated in allergic persons, persons with severe immunodeficiency, and persons with intussusception. After vaccination, it may cause fever, diarrhea, gastroenteritis, irritability and other adverse reactions. The specific vaccination program should follow the doctor’s instructions, after the use of medicine, if there is any discomfort, consult a doctor.