Long-term use of methylprednisolone will produce a series of side effects, the main effect of this drug on the heart is relatively large, will cause congestive heart failure, arrhythmia; in addition to this will also cause dizziness, muscle weakness, hypokalemia, etc., on the calcium metabolism also has a certain impact, it will lead to the emergence of lower limb weakness. There is also the possibility of inducing aseptic necrosis of the femoral head and steroidal muscle disease, which can also cause weight-bearing restriction and pain in the lower limbs, and cause symptoms of lower limb tenderness. Patients who have been taking hormones for a long time should have regular checkups and pay attention to adjusting the dosage of hormones, and stop using hormones as soon as possible if the condition is stable; however, patients should not change the dosage of hormones on their own to avoid aggravation of the disease.