Clinically, there are many sugar lovers believe that metformin will cause acidosis if the kidneys are bad, so it is said that metformin hurts the kidneys. Some people also have nausea and diarrhea after taking metformin, so it also hurts the stomach. In fact, metformin has been used in the treatment of type 2 diabetes for more than 50 years, the efficacy of sugar control and good drug safety is proven, do not need to worry too much. Metformin itself does not produce any adverse effects on the kidneys, metformin drugs in the body is almost not combined with plasma proteins, and metformin can be excreted 90% by the kidneys within 24 hours. As for the case of kidney injury, it should be that the kidney has already had problems before, not metformin injury to the kidney. The statement “Metformin should not be used in renal insufficiency” should not be taken as “Metformin hurts the kidneys”. As for the gastrointestinal reaction, many people do have such performance, but as long as you pay attention to slowly increase the dose, or pay attention to the duration of taking the drug, or switch to some enteric formulations, or extended-release agents, should not be worried. Metformin is the first-line treatment of drugs, as long as there is no obvious contraindications, rest assured that the application of the.