Nail melanoma can first be treated surgically. When the melanotic lesion is within 5 cm and the tumor thickness and embedded depth is less than 1 cm, it can be surgically removed. Secondly, it can also be treated by radiation therapy, which is effective for patients with metastases and early freckled malignant melanoma to relieve symptoms such as pain and pressure sensation. Chemotherapy and chemotherapy are not ideal for melanoma, according to relevant data, the cure rate is less than 10%, moreover, chemotherapy drugs have serious toxic side effects, and patients often have nausea, vomiting and loss of appetite after using them. Finally, biological therapy can be used to treat melanoma, using the patient’s own mononuclear cells to proliferate and culture in vitro, and then returning these cells to the patient’s body to indirectly activate the body’s immune system to resist the tumor.