High HDL and high cholesterol are mainly related to pathological factors such as primary hyperlipoproteinemia and chronic liver disease, and may also be related to physiological factors such as alcohol consumption and taking birth control pills. 1. Pathological factors: high HDL and high cholesterol are two different things, high cholesterol belongs to dyslipidemia, which is an independent risk factor for coronary atherosclerosis, for patients with high HDL and high cholesterol, but low HDL is usually of clinical significance. 2. Physiological factors: for example, athletes, generally high HDL and cholesterol, in the case of alcohol consumption, there may also be physiological high HDL and cholesterol, after removing the primary cause can be returned to normal. Patients should combine with other tests to determine the disease, and high cholesterol is an independent risk factor for atherosclerosis, which is very important and common, and needs to be taken very seriously. The cause should be identified and treated as soon as possible without delay and in accordance with medical advice.