HPV infection in the oral cavity is usually related to poor sex life, treatment should be based on anti-virus and increase immunity, methods include general treatment, physical therapy, drug therapy and so on. 1. General treatment: avoid sexual life during the course of the disease; sexual partners or spouses need to be treated at the same time; personal clothing and toiletries should be disinfected in a timely manner; pay attention to oral hygiene, daily use of saline gargling; diet should be light. 2. Physical therapy: the purpose is to remove the visible warts, can be used laser, liquid nitrogen freezing, microwave, electrocautery, surgical excision methods to remove the warts in the oral cavity. 3. medication: oral HPV infection can be oral antiviral drugs to control the condition, such as 0.5% foot leaf grass fat toxin tincture, 5% imiquimod, fluorouracil ointment, etc., if necessary, the use of interferon, thymus peptide, interleukin, etc. to regulate the immune system, to accelerate the removal of foci and to reduce the recurrence of the disease. HPV virus has a certain degree of contagiousness, should be treated in a timely manner, it is recommended to choose the treatment program under the guidance of the doctor, avoid blindly self-medication, so as not to cause adverse reactions.