Gamma-glutamyltransferase is an enzyme widely found in the human body, especially in the kidneys, pancreas, and liver. Generally, elevated gamma-glutamyltransferase may be caused by diseases of the hepatobiliary system, such as cirrhosis, or pancreatic diseases, such as pancreatitis, and may present with symptoms such as stomach pain, acid reflux, fatigue, nausea, and jaundice. 1. Hepatobiliary system diseases: such as hepatitis, cirrhosis, cholelithiasis, etc., can cause gamma-glutamyl transferase elevation, abdominal pain, fatigue, loss of appetite, nausea and vomiting, emaciation and other symptoms, and even chills, high fever, ascites, jaundice and so on. 2. Pancreatic diseases: such as pancreatitis, abdominal pain, abdominal distension, belching, nausea, vomiting, steatorrhea and other symptoms, in severe cases, petechiae may appear in the lumbar ribcage and skin around the umbilicus, which may be accompanied by fever, low blood pressure, respiratory distress and other symptoms. Elevated gamma-glutamyltransferase is recommended to consult a doctor for a clear diagnosis and targeted treatment under the doctor’s guidance.