Callus is also known as callus, callus on the palm of the hand can be treated by removing the causative factors and applying medication externally. Callus refers to the long-term pressure and friction of the skin, resulting in local keratin hyperplasia, hardening, followed by keratinized skin damage, mainly occurring in the palms of the hands and soles of the feet, in addition to the elbow and knee joints and other easy to friction parts can also be produced. The treatment is as follows: 1. Remove the trigger: patients need to avoid excessive friction and stimulation of the skin in the palm area. 2. Topical medication: patients can use urea cream or ointment to moisturize the skin, and use salicylic acid and retinoic acid cream to remove the excess keratin, the above medications should be used under the guidance of a doctor, and should not be abused blindly. In daily life, patients need to observe whether the area of callus is enlarged, whether the number is increased, whether the surrounding skin is red and swollen, if there is any abnormality, it is necessary to go to the dermatology department of the hospital for consultation.