Patients who follow the doctor’s instructions to take allopurinol one tablet a day generally will not lead to kidney damage, but need to regularly test the liver and kidney function and blood routine. Allopurinol is a kind of drug that controls blood uric acid concentration by inhibiting uric acid synthesis, the drug is mainly excreted by the kidneys, and the amount of excretion is reduced in renal insufficiency. Common drug specifications for 0.1g/tablet, 1 tablet per day is a normal dosage, exclude the corresponding drug contraindications after taking the drug does not usually appear renal damage. Allopurinol common adverse drug reactions are diarrhea, nausea, skin rash and leukopenia. Allopurinol is contraindicated in people who are allergic to the components of the drug, people with low blood counts and severe hepatic or renal insufficiency, and pregnant and lactating women. During the period of taking the drug, blood and liver and kidney functions should be checked regularly, and drink plenty of water during the period of using the drug. Allopurinol should be used under the guidance of a physician, and it is recommended that patients go to the endocrinology department and rheumatology and immunology department of a regular hospital for detailed consultation.