Pain in the knee when squatting up is mostly seen in orthopedic diseases, such as osteoarthritis, osteophytes, and lumbar disc herniation. First, osteoarthritis is most often seen in patients who work long hours with heavy physical labor, or walk for a long time, mostly in the middle-aged and elderly, mainly manifesting as pain in the knee. Especially when squatting up or going up the stairs, mainly manifested as wear and tear of joint cartilage and narrowing of the gap. Patients are recommended to have an MRI of both knees, and after a clear diagnosis, they should pay attention to rest and avoid prolonged walking, especially climbing hills and stairs, etc. If necessary, oral glucosamine capsules or intra-articular injections of sodium vitreous acid should be given. Second, osteophytes are caused by calcium deficiency or prolonged strain, patients should pay attention to calcium supplements, more sunshine, and patients with obvious osteophytes can be treated with surgery. Thirdly, the herniated intervertebral disc compresses the nerve, the patient can be accompanied by lower limb numbness, lumbar pain and other symptoms, lumbar spine CT or lumbar spine magnetic resonance examination can further clarify the diagnosis.