The late stage of uremia can have very serious consequences if treatment measures such as active renal replacement are not taken. For example, the digestive system will produce symptoms such as loss of appetite, anorexia, nausea, vomiting, taste of urine in the mouth, inflammation and ulcers in the digestive system, and serious reactions such as blood in the stool and bleeding in severe cases. In the nervous system, there are symptoms such as insomnia, numbness in the limbs or cramps in the hands and feet, blurred consciousness, coma, etc. In the blood system, various kinds of bleeding and anemia are produced. In the cardiovascular system, it will produce pericarditis and cardiac insufficiency due to the patient’s anemia and other factors. It also produces various complications such as bone disease, bone pain, proximal muscle weakness, fractures, and skin pruritus. In severe cases, it can lead to severe hyperkalemia and disorders of low acid-base metabolic balance, which can put life at risk, so it must be actively treated with renal replacement.