Cefixime and azithromycin differ in class, pharmacologic action and clinical application, adverse effects, and contraindications. 1. Category: Cefixime belongs to the third generation of cephalosporin antibiotics, while azithromycin belongs to macrolide antibiotics. 2. Pharmacological effects and clinical applications: Cefixime has strong effects on Gram-positive as well as negative bacteria, and can be used for acute bronchitis, biliary tract infections, gonococcal urethritis, cystitis and other infections caused by sensitive bacteria. Azithromycin mainly acts on Gram-positive bacteria as well as some Gram-negative bacteria, and also has better effect on Mycoplasma and Chlamydia infections. It can be used for respiratory tract infections such as acute bronchitis, skin and soft tissue infections caused by Aureobasidium and other bacteria, and genitourinary infections caused by Chlamydia and other bacteria. 3. Adverse reactions: Cefixime adverse reactions are mild and transient, mainly gastrointestinal reactions such as diarrhea, allergic reactions such as rash and urticaria, headache and dizziness. Azithromycin adverse reactions are mainly gastrointestinal reactions and allergic reactions, but also transient neutropenia and hepatotoxicity may occur. 4. Contraindications: Cefixime is mainly contraindicated in those who are allergic to cephalosporin antibiotics; Azithromycin is contraindicated in those who are allergic, and also contraindicated in those with moderate to severe hepatic insufficiency. Cefixime and azithromycin mainly in the indications and contraindications and other aspects of the existence of different, it is recommended that patients timely consultation, follow the doctor’s instructions to choose the appropriate antibiotic treatment.