Asthma is divided into many types, the most serious type of asthma is asthma persistent exacerbation, when the patient will appear repeated wheezing, continuous shortness of breath, chest tightness, shortness of breath, hypoxemia with hypercapnia, causing respiratory failure and even respiratory airway edema is more obvious, airway obstruction is very serious will cause asphyxia, so to avoid this life-threatening situation. To avoid this life-threatening condition, comprehensive treatment measures should be given, such as intravenous infusion therapy to promote dilution and discharge of inflammatory secretions in the airway and stabilize vital signs, continuous oxygenation, and the combination of bronchodilators and glucocorticoids. If necessary, mechanical ventilation is also required to improve respiratory function and stabilize vital signs, and antibiotics can be given to prevent bacterial infection.