Walden’s macroglobulinemia is a disease of unknown etiology, due to the disorderly and massive proliferation of lymphoid plasma cells in the bone marrow and the secretion of monoclonal high concentrations of immunoglobulins, mainly IgM-type immunoglobulins, resulting in a series of symptoms in patients, the vast majority of whom will develop symptoms of hyperviscosity, because IgM is highly viscous and lgM can aggregate with each other. This leads to increased blood viscosity. Patients will experience weakness, headache, loss of vision, tinnitus, blurred eyes, and in severe cases, retinal hemorrhage, venous hemorrhage, peripheral neuritis, manifesting as numbness of the extremities, etc. Sometimes congestive heart failure will also occur. There is also a pronounced bleeding tendency, such as bleeding from the nasal mucosa, gastrointestinal bleeding, and sometimes anemia, manifested as pallor and dizziness. Walden’s macroglobulinemia also presents with signs of immune deficiency, and patients frequently develop infections and sometimes second tumors.