Fever is one of the more common systemic manifestations of Crohn’s disease. Fever is caused by inflammatory activity in the intestinal tract as well as secondary infections, and is usually low or moderate in severity, while a small number of patients may develop high fever with toxemia. The main clinical symptoms of Crohn’s disease are digestive manifestations, such as abdominal pain, diarrhea, abdominal masses, and fistula formation. Patients with fever and high suspicion of Crohn’s disease require prompt e-colonoscopy to assist in a definitive diagnosis. If the presence of Crohn’s disease has been confirmed, regular medication treatment needs to be given in cooperation with a specialist. If complications arise, surgical treatment is required, such as complete intestinal obstruction, fistula and abscess formation, or acute perforation, which requires consultation with a specialist.