How long to take drospirenone ethinyl estradiol tablets is related to the purpose of the medication, such as for the regulation of menstrual cycle, generally take 3-6 months; for contraception, need to take more than 7 days continuously. Drospirenone and estradiol tablets are short-acting contraceptives, which are a combination of estrogen and progestin, mainly used for female contraception and adjusting menstrual cycle, with good effect and relatively small side effects. If taken as a short-acting contraceptive pill, it is usually taken orally on the first day of menstruation and can achieve 99% of the contraceptive effect after more than 7 days of oral intake, i.e. it can play an effective contraceptive role after 1 week of use. If it is to regulate the menstrual cycle, you can start taking the drug on the 5th day after your menstrual period and stop taking it after 21 days of continuous use, and then take the next cycle of the drug after 7 days of stopping, usually it needs to be taken orally for 3-6 months to observe the efficacy. While taking this medication, you should take it according to the instructions or as prescribed by your doctor, and take it at a fixed time every day without missing any dose, as this may cause irregular vaginal bleeding or affect the effectiveness of contraception.