A plus sign in urine bileogen is considered normal if it is not accompanied by abnormal urine color or abnormal urination, etc. In routine urine tests, urobilinogen may normally show a single plus sign or a weakly positive result without any medication or related tests. However, if there are multiple plus signs or abnormal changes in urine color, such as yellowish or dark brown urine, it is important to consider the presence of hepatocytes. The presence of hepatocellular jaundice should be considered, and liver function tests and ultrasound examinations of the liver, bile, pancreas and spleen are recommended. When hepatocellular jaundice is present, the systemic bilirubin level can be elevated, when the number of urobilinogen reabsorbed through the hepatic-intestinal circulation increases significantly. After filtration by the kidneys, dark brown urine is excreted and the test shows a strong positive result for urobilinogen. At this point, relevant treatment such as hepatoprotection and anti-yellowness is required.