Both total protein and globulin are low, which may be related to the damage of liver function as well as kidney function, commonly in the following cases: 1. Impaired liver function: total protein is divided into albumin and globulin, the vast majority of which is synthesized in the liver. If the liver is abnormal, such as after the liver is damaged by viruses, alcohol or drugs, resulting in a decrease in the synthesis capacity of the liver, the value of albumin and globulin in the blood can be reduced to a certain extent; 2, impaired kidney function: the kidney is mainly to excrete the waste produced by the body outside the body, if the filtration function of the kidney is damaged to a certain extent, resulting in albumin or globulin and other macromolecular structures can be unimpeded If the filtration function of the kidney is damaged to a certain extent, resulting in the large molecular structures such as albumin or globulin can pass through the renal tubules and enter the urine without obstruction, it will make a large amount of protein loss, thus causing hypoproteinemia. Therefore, when a patient has a significant decrease in total protein, globulin or albumin values, the cause should be identified and the protein count should be effectively restored through treatment that targets the cause.