The formation of blood pressure depends on the non-stop beating of the heart, which has a systolic and diastolic phase, and these two periods form the systolic and diastolic pressures. The difference between systolic and diastolic pressure is usually the pulse pressure difference, and the pressure difference in blood pressure refers to the pulse pressure difference. Any factor that can affect the systolic and diastolic pressure will have an impact on the pulse pressure difference, as follows: 1. Vascular sclerosis: After vascular sclerosis, the systolic blood pressure will be high, and the diastolic blood pressure will be lower because the elastic retraction rate of the aorta decreases. So with atherosclerosis, the pressure differential will increase, and this is mostly seen in the elderly. 2, fast and slow heartbeat: the pressure differential will become smaller when the heartbeat is fast, while the pressure differential will become larger when the heartbeat is slow. 3, the impact of the heart valves: in particular, the aortic valve closure is incomplete or there is hyperthyroidism, these conditions will affect the pressure differential.