Sudden stomach cramps in the middle of the night may be due to cold at night, excessive consumption of dinner, gastrointestinal disorders, and so on. It can be relieved by emergency means, medication and timely medical treatment. 1. Emergency means: common such as drinking hot water to warm the stomach, warm water bags or hot compresses on the palm of the hand to warm the stomach, clockwise massage of the stomach to relieve colic. 2. medication: acute gastritis patients in the middle of the night gastric colic, can follow the doctor’s instructions to take atropine sulfate tablets, scopolamine tablets and other drugs to relieve pain. Duodenal ulcer caused by the middle of the night gastric colic can be prescribed to take ranitidine hydrochloride capsules, famotidine tablets and other drugs to relieve pain. Peptic ulcer or gallbladder stones caused by gastric colic can be prescribed to take omeprazole, lansoprazole, rabeprazole and other drugs. 3. Timely medical treatment: If gastric colic is caused by abnormal diet before bedtime, timely medical treatment is recommended. There are many causes of sudden gastric cramps in the middle of the night, if the pain is unbearable, it is recommended to consult a doctor in time to clarify the cause of the disease, do not delay and lead to the deterioration of the disease. Medications should be used under the guidance of a doctor.