Inflammation of enlarged mandibular lymph nodes is mainly caused by pathogenic microorganisms, and antibiotics can be used under doctor’s supervision to control inflammation, improve symptoms and promote recovery from the disease. When patients are infected with pathogenic microorganisms, the inflammation will stimulate the lymph nodes to cause swelling and pain. Patients can take antibiotics such as penicillin, clindamycin, doxycycline, ceftriaxone and other drugs to control inflammation and relieve discomfort. As the drug does not exist the absolute safest and most effective, need to strictly follow the doctor’s instructions regulate the use of adverse reactions such as headache, nausea, diarrhea, rash, etc. timely medical treatment, drug allergy is prohibited, cephalosporins in the use of alcohol during the use of the drug is prohibited.