The presence of intrahepatic cholestasis in pregnancy can be treated by bile acid-lowering therapy, adjuvant therapy, and obstetric management. 1. Bile acid lowering therapy: medications such as ursodeoxycholic acid and S-adenosylmethionine can be used under the guidance of a doctor to control the progression of the disease. Liver function and bile acid level need to be checked every 1-2 weeks to understand the condition and response to treatment. 2. Adjunctive treatment: Dexamethasone can be used if there is a risk of preterm labor, and glycerite lotion can be used to improve itching symptoms, and attention should be paid to monitoring the fetal heart rate. 3. Obstetric treatment: Pregnant women with this disease may have sudden and unpredictable intrauterine death, and need to grasp the timing of the end of labor. In severe cases, the pregnancy should be terminated promptly. Intrahepatic cholestasis in pregnancy requires prompt medical attention and treatment as prescribed by the doctor.