Long-term gastritis with gastric angle glandular epithelial high-grade adenoepithelial neoplasia suggests precancerous lesions, and the treatment includes general treatment and surgical treatment. 1. General treatment: avoid overeating, keep a light diet, avoid taking drugs that damage the gastric mucosa, such as aspirin. 2. Surgical treatment: high-grade intraepithelial neoplasia, according to the scope and depth of involvement, choose endoscopic resection or surgical resection, it is recommended to go to the hospital to do ultrasonic endoscopy and abdominal enhancement CT and other examinations, according to the results of a comprehensive decision on the treatment method. After surgical resection of localized diseased tissue, regular review is required. Patients with long-term gastritis who are found to have gastric angle glandular epithelial high-grade adenoepithelial neoplasia are recommended to go to the hospital to avoid delayed treatment.