Common causes of thigh bone pain at night include overwork, osteoporosis, lumbar disc herniation, tumor, etc. If the symptoms persist, it is recommended to seek medical treatment in time. 1. Overexertion: If patients have strenuous physical activities or heavy physical work during the day, it is easy to cause lactic acid to accumulate at the muscles, and lactic acid metabolism at night, which can produce pain in the thigh bone. 2. Osteoporosis: the loss of matrix in the bone and the decrease of bone formation will cause osteoporosis, usually no obvious symptoms, but some patients will feel the generalized hidden pain, and there will be the performance of thigh bone pain at night. 3. Herniated lumbar disc: when the herniated lumbar disc compresses the nerve root, it is easy to cause pain and numbness in the lower limbs. 4. Tumor: If there is a tumor at the thigh bone, when the tumor presses the surrounding soft tissues, the phenomenon may also occur. The causes of thigh bone pain at night are more reasons, may also be related to the lower limb thrombosis, old injuries and other reasons, it is recommended to go to the hospital in time, by the doctor to identify the cause of the disease, targeted treatment.