Folic acid deficiency in ischemic patients can lead to megaloblastic anemia, so megaloblastic anemia patients need to take folic acid supplements. For menopausal women, if there are no symptoms of megaloblastic anemia due to folic acid deficiency, there is no need to improve the symptoms by supplementing folic acid, so folic acid supplementation for menopausal women, is not necessary. However, folic acid is a must for pregnant women, folic acid is the main component of vitamin B synthesis, which can prevent neural tube malformation, and there are definite conclusions.