Levofloxacin and azithromycin do not need to be taken at intervals, they can be taken together, and it is recommended that they be taken separately according to the appropriate instructions for the drug. Levofloxacin is one of the quinolones, which has a strong antibacterial effect on most gram-negative bacteria such as Enterobacteriaceae. Azithromycin is more effective in lower respiratory tract infections such as bronchitis and pneumonia caused by sensitive bacteria. Levofloxacin and Azithromycin can be taken at the same time without any time interval, but pay attention to their dosage, for example, Azithromycin should be taken 1 hour before meal or 2 hours after meal. In addition, if it is the first time to take it, you may consider taking it at an interval of more than half an hour, in order to facilitate the observation of whether there is any allergic reaction to a certain drug and other circumstances. At the same time, if the simultaneous administration causes adverse reactions such as gastrointestinal reactions that are more pronounced or intolerable to the patient, consider taking the two medications a few hours apart. Levofloxacin and azithromycin do not need to be taken at intervals, they can be taken together, and it is recommended that they be taken according to the instructions under the guidance of a doctor.