The aggravation of gout after taking febuxostat may be related to the decrease of blood uric acid after taking the drug, and the transfer of uric acid deposited in the tissues induces the aggravation of gout symptoms.
After taking febuxostat uric acid-lowering drugs, serum uric acid will drop, and the uric acid deposited in the tissues (such as skin soft tissues, blood vessels, kidneys, etc.) is dissolved, and the dissolved uric acid is transferred to the blood vessels, and fluctuations in uric acid can form new crystals and deposits, causing acute attacks of gouty arthritis.
Gout patients treatment, pay attention to not make uric acid drop too fast, take uric acid-lowering drugs need to start from a small dose, to avoid large fluctuations in uric acid.
Patients whose gout worsens after taking febuxostat are advised to go to the rheumatology and immunology department of regular hospitals for treatment under the guidance of a doctor, and not to use drugs blindly.