Cheek pain while chewing may be caused by chewing for a long time, or it may be caused by dental caries, temporomandibular arthritis and other diseases. 1. Chewing for a long time: If you chew gum or betel nut for a long time, it will easily lead to temporomandibular joint disorder, and if it is serious, you may have pain in the cheek when chewing. 2. Dental caries: It may be due to the frequent lack of attention to oral hygiene, or often eat foods high in sugar, resulting in the destruction of the hard tissues of the teeth, which can lead to the formation of dental caries. When chewing food, the tissues or nerves around the decayed teeth will be affected, which will cause pain in the cheek when chewing. 3. Temporomandibular arthritis (TMJ): It may be due to trauma to the face or grinding teeth at night, which leads to damage to the chewing muscles and induces TMJ, resulting in pain in the cheek when chewing. Patients who experience pain in the cheek when chewing should go to the hospital in time for targeted treatment to avoid delaying their condition.