Amoxicillin and Vicodin can be taken together and need to be used under the supervision of a doctor. Amoxicillin belongs to anti-inflammatory drugs, which act as an antiseptic and anti-inflammatory. Vitamin C belongs to the vitamin tablets, it mainly helps the body to supplement vitamin C. Amoxicillin and Vitamin C can be taken together, there is no interaction between the drugs, and there is no drug antagonism, so it can be put together. Amoxicillin may have adverse reactions such as diarrhea, nausea and vomiting after oral administration, and is contraindicated in patients who are allergic to penicillin and have a positive penicillin skin test. For other – lactam agents (such as cephalosporins, carbapenems, monocyclic – lactams) have serious rapid hypersensitivity reactions (such as allergic reactions) is prohibited. Prolonged application of large amounts of vitamin C may cause urate, cysteinate or oxalate stones. Contraindications are unclear. It is recommended that when patients want to take amoxicillin and vitamin C at the same time, this should be done under the supervision of a medical professional.