The price of Down screening is 250-300 dollars, and the price of non-invasive is 2000-2500 dollars. There are some differences in the charges of different regions and different levels of hospitals. Down screening is prenatal screening for Down syndrome, which is mostly performed between 14-20 weeks of pregnancy. It is necessary to take the blood of the pregnant woman and test the maternal serum for alpha-fetoprotein, chorionic gonadotropin (HCG) and free estriol. Combined with the age, weight and gestational week of the pregnant woman, the risk coefficients of the fetus for congenital stupidity and neural tube defects will be calculated by the software. The cost of Down screening is about $250-300 and is now free in many areas. Non-invasive is a non-invasive DNA test in which a pregnant woman’s venous blood is drawn to extract fragments of fetal DNA to further determine whether the fetus is at risk for Down syndrome. This test is mainly for pregnant women who are at high risk of Down’s syndrome, and costs 2,000-2,500 RMB, with most areas subsidizing the cost, so you need to consult your local family planning department. Both Down screening and non-invasive tests belong to the prenatal screening program, Down screening is a kind of large-scale screening, and non-invasive is a further examination for people with Down screening abnormality, and its accuracy rate is higher.