After 2 micro-invasive lung adenocarcinoma surgeries, 12mm lung nodule grows again, which may be caused by recurrence of lung cancer, infection, tuberculosis and so on, and needs to be treated with different treatment plan according to the cause. 1. Lung cancer recurrence, for nodules caused by lung cancer recurrence, it is necessary to determine the treatment plan according to the patient’s physical condition. If the patient’s physical condition is still good and he/she can still tolerate the surgery, then he/she can continue to undergo surgical resection, but it is recommended to cooperate with radiotherapy, chemotherapy and other treatments after the surgery. 2. Infection, if the inflammation is caused by bacterial or viral infection, antibiotics and antiviral drugs are needed to carry out targeted treatment, commonly used drugs include moxifloxacin and cefradine. 3. Tuberculosis, nodules caused by tuberculosis need to be treated with anti-tuberculosis drugs such as rifampicin and isoniazid.