Breast nodules and hyperplasia are different in terms of definition, nature, clinical manifestation and treatment. 1. Definition: Breast nodule is a breast lump found by physical examination or imaging, which is a manifestation of breast disease. Breast hyperplasia, also known as cystic hyperplasia of the breast, is an uneven proliferation of various parts of the breast tissue caused by estrogen and progesterone imbalance. 2. Nature: Breast nodules include benign non-neoplastic diseases such as mastitis and breast hyperplasia, benign tumors such as breast fibroids, and malignant tumors such as breast cancer. Breast hyperplasia can be manifested as breast nodules on imaging, which is a benign non-tumor disease. 3. Clinical manifestations: Breast nodules of different natures can have different symptoms, such as breast cancer can manifest as lumps, cellulite, breast skin dimpling, etc. Breast fibroma manifests as painless and tough lumps. Breast hyperplasia can be manifested as breast swelling and pain and lumps before and during menstruation, and the symptoms will be reduced significantly after menstruation. 4. Treatment: Different treatments for different nature of breast nodules, generally acute mastitis need to take antibiotic treatment with penicillin such as cefdinir, incision and drainage after abscess formation; breast cancer needs radical surgery, endocrine therapy, chemotherapy and other comprehensive treatment. Breast hyperplasia is mostly treated symptomatically, and can be treated with medicines such as breast fetish dispersal capsule and tamoxifen, and those with lumps need to be followed up regularly. Those with breast nodules and hyperplasia should consult a doctor for further examination and treatment.