It is important to properly assess each person exposed to an environment with extravasated medication. If someone’s skin or clothing comes into direct contact with the drug, the contaminated skin must be washed immediately with soap and water. Before handling extravasated drugs, the first step is to protect yourself by wearing your uniform, putting on two pairs of powder-free latex sterilized gloves, plus two masks, and washing your hands before putting on and after taking off the gloves. The permeability of the gloves increases with time, and the gloves usually need to be replaced every 60 min of operation or if they are broken, punctured, or stained with drugs. If there is a lot of extravasated drug, the eyes and face should be protected, such as eye shields and face shields to prevent possible drug spills, this protection is not provided by ordinary glasses, need professional anti-spill glasses. And if the extravasated drug produces vaporization, a respirator is required. After the self-protection work is done, the treatment of extravasated medication begins. The extravasated medication is adsorbed with gauze, while the powder is gently wiped with a sponge, and all contaminated items are placed in yellow double-layer medical garbage bags, sealed to avoid contaminating the room air, and marked with a clear warning mark. The place contaminated by drug extravasation should be repeatedly cleaned three times with detergent and then cleaned with water. In the case of wearing personal protective equipment, the items that need to be used repeatedly should be washed twice with detergent and then washed with clean water. The last yellow special garbage bag with cytotoxic drug contamination should be sealed and put into another yellow medical special garbage bag. The protective clothing of all personnel involved in the removal of the extravasated drug should be discarded in the outer yellow medical garbage bag, and the outer yellow medical garbage bag should be sealed and placed in a special disposable sharps box for cytotoxic waste. The name of the drug, the approximate amount of extravasation, how the extravasation occurred, how the extravasation was handled, who was exposed to the extravasation, etc.