Diabetic patients can experience weight gain during the treatment process, commonly due to two reasons, as follows: 1. The body type is thin at the onset of diabetes, and early standardized glucose-lowering treatment corrects the disorder of glucolipid metabolism, which can restore the weight to the normal range, and the patient’s weight will not show a progressive increase. 2. Oral hypoglycemic drugs, especially oral drugs that promote insulin secretion, such as hypoglycemic pills, euglycemia, glipizide, and gliclazide, because these drugs promote insulin secretion and promote the synthesis function, and weight gain can occur. Glipizide, Glipizide, because such drugs promote the secretion of insulin and promote the synthesis function, weight gain can occur, especially if the patient’s diet is not strictly controlled. In addition patients who apply insulin can also experience weight gain. Therefore, it is very important to monitor the weight of patients with type 2 diabetes. If the weight shows a progressive increase, we must pay attention to adjusting the dose of glucose-lowering drugs and pay attention to whether the patient has strict dietary control.