Hidden pain in liver area may be caused by chronic hepatitis, fatty liver, cirrhosis, liver cancer, chronic cholecystitis, gallbladder stones, etc., which need to be treated with medication or surgery according to the cause. 1. Chronic hepatitis: Hepatitis B virus infection leads to the destruction of liver cells and tissues, thus causing vague pain in the liver area, which can be treated with antiviral drugs such as entecavir, tenofovir, interferon, emtricitabine and dalatasvir. 2. Fatty liver: large amount of fat in the liver cells and liver tissue stagnation leads to steatosis of liver cells, so the pain in the liver area, you can use oseltamivir, fenofibrate, atorvastatin, silymarin and other drugs to treat it, and actively exercise to reduce weight and reduce fat intake. 3. Cirrhosis: Chronic necrosis and apoptosis of the liver with extensive fibrosis, pseudo lobar formation, destruction of normal liver structure and vague pain in the liver area. It can be treated by jugular vein portosystemic shunt, endoscopic injection of sclerosing agent to stop bleeding, liver transplantation and so on. 4. Hepatocellular carcinoma: In the middle and late stages, the enlargement of hepatocellular carcinoma can stimulate the nerve fiber of hepatic peritoneum and cause vague pain in the liver area, which needs to be treated by surgical resection of the tumor tissue, radiotherapy, chemotherapy and targeted therapy. 5. Chronic cholecystitis: chronic inflammatory lesions of gallbladder cause vague pain in liver area, which can be treated by taking ursodeoxycholic acid, atropine, diclofenac sodium, piperacillin, ceftazidime and other drugs. 6. Gallbladder stones: Stones irritate the gallbladder wall, resulting in breakage and bleeding and vague pain in the liver area. When there is an indication for surgery, it can be treated by surgery. Pay attention to the use of drugs under the guidance of a physician.