The human body notices symptoms of pus in the urethra and needs to be examined for discharge. A common factor for the presence of purulent discharge from the urethra is a localized infection, more commonly pus-filled bacteria, such as E. coli. This condition can be treated symptomatically with routine oral antibiotics, such as levofloxacin and cefixime. If the patient has recently had unclean sex, and cause the urethra has pus discharge oozing this situation, mostly gonococcal infection. Gonorrhea can be treated with an intravenous infusion of ceftriaxone, which routinely requires 7-10 days of treatment, with follow-up after treatment to assess whether the medication is working. Alternatively, a culture of the discharge can be performed and a drug sensitivity test can be performed to select a sensitive antibiotic for effective treatment. Therefore, in the case of urethral discharge, the specific pathogen should be clarified, and sensitive antibiotics should be selected for treatment in order to have a good therapeutic effect.