Fibularis longus interspace cysts can be treated with hormonal therapy or surgery, depending on the size and nature of the cyst. 1. Hormonal treatment: If the cyst is small, hormonal drugs such as prednisone acetate and methylprednisolone can be injected into the cystic area of the peroneal interosseous space for anti-inflammatory treatment, inhibiting the exudation of peroneal interosseous space cysts and killing the cysts. 2. Surgery: If the cyst is large, irregular in structure, or reappears after medication, cyst excision can be performed, and the cyst can be removed by complete stripping as much as possible to reduce the possibility of recurrence. After the treatment of peroneal longissimus intermedius cysts, we should review regularly, and if there are obvious discomfort symptoms, we need to consult the doctor in time.