Sertraline and citalopram does not exist which is safer, only suitable for their own disease is the safest, at the same time the use of drugs need to follow the doctor’s instructions. Sertraline is a selective 5-hydroxytryptamine reuptake inhibitor, used in the treatment of depression, anxiety disorders, bipolar disorder of depression, and so on. The side effects of sertraline are few and mild and overall safe, but some patients may experience side effects such as excessive sweating, dry mouth, dizziness and nausea. It is contraindicated in people who are allergic to sertraline. Combination with monoamine oxidase inhibitors (MAOI) and pimozide is prohibited. Citalopram is a new antidepressant drug, mainly used for the treatment of patients with depression or anxiety disorders, citalopram has no sedative effect, only the role of uplifting the spirit. Citalopram’s adverse reactions are very mild, rarely appear larger adverse reactions, but long-term use will lead to some patients with symptoms of excitability. It is contraindicated for those who are allergic to the product. Both of these drugs are used to treat depression and anxiety, so it is safest to choose the one that is suitable for your disease, and the drugs should be used in accordance with medical advice.