The elderly are more or less chronic diseases, and long-term medication, and certain fruits and drugs together are prone to adverse reactions, and even bring serious consequences, such as taking antihypertensive drugs when you can not eat this fruit. Antihypertensive drugs + grapefruit can induce stroke and heart attack! According to the Wuhan Evening News, Huang is 62 years old and has a history of hypertension for nearly 10 years, and has been taking antihypertensive drugs on time, his blood pressure is well controlled. After dinner he just ate half a grapefruit, he began to feel dizzy and panic, general weakness, the family thought it was hypertension, immediately to Huang Dad blood pressure test, the results are surprising, the instrument shows that the blood pressure is only 70/40, belongs to the hypotension, scared family members rushed Huang Dad to the hospital. After examination, Huang ruled out the possibility of a stroke, the doctor confirmed his diagnosis of hypotension. Grapefruit contains potassium, itself can lower blood pressure, in taking antihypertensive drugs, if you eat grapefruit at the same time, it is like increasing the dose of antihypertensive drugs, will make a significant drop in blood pressure in the short term, may induce a stroke and heart attack. Grapefruit has a greater effect on the drug than the average grapefruit, and if grapefruit is eaten before and after taking the drug, it can still cause blood pressure fluctuations even if 4 hours have passed. Mechanism of action Grapefruit = grapefruit ≠ grapefruit ≠ orange ≠ orange (sweet orange, blood orange, navel orange) ≠ orange, which will not be unfamiliar to the foodies. Grapefruit juice contains furanocoumarins, which irreversibly inhibit cytochrome P450 enzymes (such as CYP3A4), and after this enzyme is inhibited, it leads to an increase in the absorption of drugs into the body. Some people will say, I paid for the drug, the more the body absorbed is not the better? This grapefruit juice is really a good thing, can increase the absorption of drugs, the body does not absorb it is not a waste of time? In fact, it is not so. The drug in the dose design process, in fact, is to take into account the body can absorb the active ingredients. For example, I take a few tablets of drugs, the body can absorb how much is the most appropriate, these are tested. For example, a hypertensive patient, taking a piece of antihypertensive drugs, according to the normal projection, the absorption of 50% of the drug, the effect of lowering blood pressure at this time just good, but because after taking grapefruit juice, will lead to increased absorption of drugs, at this time, it is possible to make the blood pressure drop too low, dizziness, headache, loss of appetite, fatigue, pale and other symptoms. These drugs can not be taken with grapefruit (juice) Doctors remind that during the grapefruit, it is best not to take antihypertensive drugs, lipid-lowering drugs, sleeping pills, anti-allergy drugs, to avoid unnecessary damage to the body. So if you or your family members are taking the following drugs, remember not to eat with grapefruit! According to reports, Canadian researchers published a paper in the Canadian Medical Association Journal that as many as 85 drugs taken with grapefruit juice can cause adverse reactions and may even lead to sudden death and other serious side effects. Grapefruit and drugs taken together can greatly amplify the drug’s effects. Every year, there are reports of serious consequences due to drugs taken together with grapefruit and grapefruit juice. If you or someone around you is unfortunately sick and needs to take the above drugs, you should remember that grapefruit and the above drugs cannot be taken together.