Sildenafil is generally taken with caution by patients with renal insufficiency. Sildenafil is mainly used for the treatment of erectile dysfunction, generally normal people will not cause damage to the kidneys after taking it, sildenafil is mainly excreted from the liver, but if patients with renal insufficiency take it, it may also lead to renal excretory dysfunction, which may aggravate the original condition, so patients with renal insufficiency are generally cautious to take it. At the same time, sildenafil can enhance the antihypertensive effect of nitrate, so patients taking any dosage form of nitrate, whether taken regularly or intermittently, are contraindicated. It is also contraindicated in patients who are hypersensitive to any of the components of the product. If patients need to use sildenafil, it is recommended to use the drug under the guidance of a doctor, not blindly self-medication to avoid adverse effects.