The soles of the feet long small blisters (i.e. “blisters”) may be physiological factors, such as local skin wear and tear, etc.; may also be caused by pathological factors, such as tinea pedis, contact dermatitis. 1. Physiological factors: common such as local skin abrasion, shoes and socks do not fit the feet of the local grinding blisters, first of all, we should replace the appropriate shoes and socks, keep the local clean and dry, if the local infections, can be coated with fusidic acid cream. 2. Pathological factors: (1) Tinea pedis: this disease is often caused by fungal infection, manifested as blisters on the soles of the feet, flaking and so on, accompanied by local itching, if there are shoes and socks that are not breathable, the environment of the feet is humid and sultry, the above symptoms may be aggravated, and can be coated with miconazole nitrate cream, naftifine ketoconazole cream, and other antifungal drugs. (2) Contact dermatitis: This disease is an allergic reaction caused by skin contact with allergenic substances. Erythema, papules and pimples will appear on the contact area, which can be manifested as small blisters on the soles of the feet with itching. Treatment should be promptly detached from the allergens, under the guidance of the doctor external glucocorticoid ointment, oral antihistamine drugs. It is recommended that patients with small blisters on the soles of their feet exclude physiological factors, go to a regular hospital in time to make a clear diagnosis, and standardize the treatment under the guidance of the doctor.