Patients with acute cerebral infarction who have not undergone thrombolysis should be given aspirin as early as possible within 48 hours, but clopidogrel can be substituted in case of aspirin allergy or inability to use it. Patients with an NIHSS score ≤3 within 24 hours of onset should be given aspirin combined with clopidogrel as early as possible for 21 days to prevent early recurrence of stroke. Acute noncardiac TIA with a high risk of stroke recurrence (ABCD2 score ≥4) within 24 hours of onset should be treated with aspirin combined with clopidogrel for 21 days as early as possible. Thereafter, either aspirin or clopidogrel can be used as first-line agents for long-term secondary prevention. The combination of unstable angina and coronary stenting is a special case and may require dual antiplatelet therapy or even combined anticoagulation. Adverse effects of aspirin include dyspepsia, bleeding, and rash. Contraindications are severe hepatic, renal, and cardiac failure, and gastrointestinal ulcers. Clopidogrel bisulfate adverse reactions include nosebleeds, dyspepsia diarrhea. Contraindications are severe hepatic damage, active bleeding and severe hepatic damage is prohibited, etc. Patients with cerebral infarction need to go out of the hospital immediately and actively cooperate with the doctor’s treatment. All of the above drugs should be used under the guidance of a doctor.